Invention Grant
- Patent Title: Substituted bicyclic heterocyclic compounds
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Application No.: US16094288Application Date: 2017-04-19
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Publication No.: US10851108B2Publication Date: 2020-12-01
- Inventor: Prashantha Gunaga , Jeremy Richter , Navnath Dnyanoba Yadav , Manoranjan Panda , Sreenivasulu Godesi
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Mary K. VanAtten
- International Application: PCT/US2017/028231 WO 20170419
- International Announcement: WO2017/184662 WO 20171026
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D487/04 ; C07D471/04 ; C07D271/04 ; C07D407/04 ; C07D407/06 ; C07D413/14 ; C07D519/00

Abstract:
Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR4 or N; Y is CR4 or N, provided that Y is N only if X is N; R1 is Formulae (A) or (B); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, R3, R4, L1, R1a, R1b, R1c, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
Public/Granted literature
- US20190127380A1 SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS Public/Granted day:2019-05-02
Information query
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