Invention Grant
- Patent Title: Method for the selection of antibodies against BCMA
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Application No.: US15945554Application Date: 2018-04-04
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Publication No.: US10851171B2Publication Date: 2020-12-01
- Inventor: Minh Diem Vu , Klaus Strein , Ekkehard Moessner , Ralf Hosse , Oliver Ast , Anne Freimoser-Grundschober , Marina Bacac , Tanja Fauti , Christian Klein , Pablo Umana , Samuel Moser
- Applicant: ENGMAB SARL
- Applicant Address: CH Boudry
- Assignee: ENGMAB SARL
- Current Assignee: ENGMAB SARL
- Current Assignee Address: CH Boudry
- Agency: Eckert Seamans Cherin & Mellott, LLC
- Priority: EP13000570 20130205; EP13000571 20130205
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; C07K16/30 ; G01N33/68 ; C07K14/705 ; C07K14/715 ; C07K14/725 ; C12N5/07 ; C12N15/63 ; A61K39/00
Abstract:
An antibody specifically binding to human BCMA, characterized in that the binding of said antibody is not reduced by APRIL and not reduced by BAFF, said antibody does not alter APRIL-dependent NF-κB activation, BAFF-dependent NF-κB activation, and does not alter NF-κB activation without BAFF and APRIL is useful as a therapeutic agent.
Public/Granted literature
- US20180222991A1 METHOD FOR THE SELECTION OF ANTIBODIES AGAINST BCMA Public/Granted day:2018-08-09
Information query
