Invention Grant
- Patent Title: Methods and compositions for treating a proprotein convertase subtilisin kexin (PCSK9) gene-associated disorder
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Application No.: US16744689Application Date: 2020-01-16
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Publication No.: US10851377B2Publication Date: 2020-12-01
- Inventor: Kevin Fitzgerald
- Applicant: Alnylam Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: McCarter & English, LLP
- Agent Maria Laccotripe Zacharakis; Deborah L. Nagle
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113 ; A61K31/7115 ; A61K31/713 ; A61P3/06 ; A61K9/00 ; A61K39/395 ; A61K45/06
Abstract:
The invention relates to methods of inhibiting the expression of a PCSK9 gene in a subject, as well as therapeutic and prophylactic methods for treating subjects having a lipid disorder, such as a hyperlipidemia using RNAi agents, e.g., double-stranded RNAi agents, targeting the PCSK9 gene.
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