Invention Grant
- Patent Title: Left-handed gamma-peptide nucleic acids, methods of synthesis and uses therefor
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Application No.: US15308901Application Date: 2015-05-08
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Publication No.: US10851407B2Publication Date: 2020-12-01
- Inventor: Danith H. Ly , Wei-Che Hsieh , Iulia Sacui , Arunava Manna
- Applicant: Carnegie Mellon University
- Applicant Address: US PA Pittsburgh
- Assignee: Carnegie Mellon University
- Current Assignee: Carnegie Mellon University
- Current Assignee Address: US PA Pittsburgh
- Agency: The Webb Law Firm
- International Application: PCT/US2015/029945 WO 20150508
- International Announcement: WO2015/172058 WO 20151112
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/686 ; C07K14/00 ; C12Q1/6858
Abstract:
A method of making optically pure preparations of chiral γPNA (gamma peptide nucleic acid) monomers is provided. Nano structures comprising chiral γPNA structures also are provided. Methods of amplifying and detecting specific nucleic acids, including in situ methods are provided as well as compositions and kits useful in those methods. Lastly, methods of converting nucleobase sequences from right-handed helical PNA, nucleic acid and nucleic acid analog structures to left-handed γPNA, and vice-versa, are provided.
Public/Granted literature
- US20170058325A1 Left-Handed Gamma-Peptide Nucleic Acids, Methods of Synthesis and Uses Therefor Public/Granted day:2017-03-02
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