Systems and methods for configuring the layout of a hovering keyboard using gestures are described. In some embodiments, an Information Handling System (IHS) may include a processor and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution by the processor, cause the IHS to: detect a hand gesture using proximity sensors disposed on a hovering keyboard coupled to the IHS, and configure a layout of the hovering keyboard based on the detection.