The present disclosure provides an information handling system (IHS) and related methods that use physical presence verification to establish unique trust relationships between boot firmware and one or more individual applications provided within an IHS. The IHS and methods disclosed herein provide secure verification of user physical presence by verifying the physical presence of a user during a pre-boot phase of the boot firmware (i.e., before an operating system (OS) is loaded and running). After user physical presence is verified during the pre-boot phase, the IHS and methods disclosed herein generate a physical presence (PP) bind token during OS runtime that may be used to establish a unique trust relationship between the boot firmware and one or more individual applications provided within the IHS.