Systems and methods for providing a tamper-proof, dual-boot Information Handling System (IHS) having Operating System (OS)-specific hardware and/or firmware components. In some embodiments, a method may include: producing, by an Embedded Controller (EC) of an IHS, a Real-Time Clock (RTC) battery-powered General-Purpose Input/Output (GPIO) control or external latch; applying the RTC battery-powered GPIO control to a chip select circuit; and selecting, via the chip select circuit: (i) a first flash memory configured to boot the IHS into a diagnostic mode or first OS, or (ii) a second flash memory configured to boot the IHS into a native OS.