Some examples described herein relate to global mapping of program nodes of a netlist of an application. In an example, a design system includes a processor and a memory coupled to the processor. The memory stores instruction code. The processor is configured to execute the instruction code to obtain a netlist of an application. The netlist contains program nodes and respective edges between the program nodes. The application is to be implemented on a device comprising an array of data processing engines. The processor is also configured to execute the instruction code to generate a global mapping of the program nodes based on a representation of the array of data processing engines and using an integer linear programming (ILP) algorithm; generate a detailed mapping of the program nodes based on the global mapping; and translate the detailed mapping to a file.