Systems and methods for alerting a user to safety hazards in real-world while the user is wearing a Head-Mounted Display (HMD). In some embodiments, an Information Handling System (IHS) may include: a processor; and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution by the processor, cause the IHS to: receive an image during execution of a xR application displayed to a user wearing a Head-Mounted Display (HMD) coupled to the IHS; detect an object in the image; associate the object with a landmark selected among a plurality of landmarks usable by the xR application to determine a position of the HMD; and provide to the user, via the HMD, a safety instruction related to the object in response to a distance between the HMD and the selected landmark meeting a distance threshold.