Systems and methods to generate purchase suggestions are disclosed. Exemplary implementations may: present purchase suggestions, by a user interface to the vehicle occupant; generate output signals conveying a location of the vehicle; receive and determine output signals of external resources conveying interest information of the vehicle occupant; determine, based on the output signals, location of the vehicle; determine, based on the location and vehicle-to-infrastructure communications, business information of one or more businesses nearby; build one or more business profiles; build one or more purchase profiles; store the one or more business profiles and/or purchase profiles in electronic storage; determine, based on the one or more business profiles, the driver's purchase profile, and/or the location information, purchase suggestions for the driver; and present, through the user interface, the purchase suggestions for the driver.