In one example, an electrostatic discharge (ESD) protection circuit includes a first power supply having a first supply voltage, wherein the first power supply is connected to a first node. The ESD protection circuit also includes a second power supply having a second supply voltage, wherein the second power supply is connected to the first node. The ESD protection circuit also includes an inverter that receives an input voltage from the first node and produces an output voltage. An ESD discharge device receives the output voltage and provides a discharge path for the first power supply and the second power supply if the output voltage indicates occurrence of an ESD event affecting the first power supply or the second power supply.