A power generation cell or a fuel cell includes an MEA, a first separator, and a second separator. A frame member is provided on an outer peripheral portion of the MEA. The frame member includes a frame member inner peripheral portion and a frame member outer peripheral portion held between the first separator and the second separator. The central position of a power generation area of the MEA in the thickness direction and the central position of the frame member outer peripheral portion in the thickness direction are offset from each other. Further, a first seal line of the first separator and a second seal line of the second separator, sealing the frame member outer peripheral portion, are non-symmetrical with each other.