Systems and methods for managing network connections and priorities based on device profiles are described. In some embodiments, an Information Handling System (IHS) may include a processor and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution by the processor, cause the IHS to: receive instrumentation data from a plurality of devices coupled to the IHS via a network; receive observation data from the plurality of devices; correlate the observation data with the instrumentation data; and configure communications between the IHS and one or more the plurality of devices based, at least in part, upon the correlation.