A picture frame hanging assembly that includes a pair of brackets each respectively directly coupled at least one of a horizontally and a vertically oriented frame elements and each bracket enclosing and defining hook-receiving aperture superimposed over a frame cavity of the picture frame and with an aperture width. The assembly includes a pair of hook components directly coupled to a building wall surface and with a cantilevered hook member extending therefrom an offset length from a front surface of the hook components to define a bracket placement zone with one of the pair of brackets disposed therein and having an inner surface with an inner surface hook width spanning from terminal opposing lateral sides thereon and at least partially supporting an upper wall of the respective one of the pair of hook components, the aperture width at least approximately twice or greater than the inner surface hook width.