Wheeled transport carts are described which are configured for transporting drain cleaning equipment such as drain cleaning machines and drain cleaning cable. The carts include engagement provisions that enable a drain cleaning machine to be affixed to the cart and preclude unintended separation from the cart during use or transport. The engagement provisions also enable the drain cleaning machine to be quickly and easily separated from the cart. Also described are methods of transporting such equipment using the carts. In addition, systems of the cart(s) with various equipment are described.