Invention Grant
- Patent Title: Composition for inducing cell reprogramming
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Application No.: US15323342Application Date: 2015-06-30
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Publication No.: US10858321B2Publication Date: 2020-12-08
- Inventor: Yong Chul Kim , Darren R. Williams , Da Woon Jung , Jung Eun Lee , Shin Ae Seo , Ji Yeon Park
- Applicant: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Gwangju
- Assignee: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Gwangju
- Agency: Hauptman Ham, LLP
- Priority: KR10-2014-0081889 20140701
- International Application: PCT/KR2015/006718 WO 20150630
- International Announcement: WO2016/003169 WO 20160107
- Main IPC: C07D231/56
- IPC: C07D231/56 ; A61K31/416 ; A61K31/415 ; C07D401/12 ; C12N5/077

Abstract:
The present invention relates to a composition for inducing cell reprogramming. The indazole derivative compound contained in the composition of the present invention shows an improved biological profile and at the same time can perform efficient cell reprogramming. In addition, unlike conventional compounds (e.g. riversine or BIO) for inducing low-molecular cell reprogramming, the indazole derivative compound of the present invention does not show cytotoxicity and thus is expected to have high growth in the market of cell therapy products when clinically applied. Conventional indazole derivative compounds have never known as a use for cell reprogramming. Compared with conventional indazole derivative compounds, the compound of the present invention has a great cell reprogramming ability while having no or little cytotoxicity.
Public/Granted literature
- US20170158642A1 COMPOSITION FOR INDUCING CELL REPROGRAMMING Public/Granted day:2017-06-08
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