The present disclosure relates to the technical field of cryogenic cooling. In particular, the present disclosure relates to a mechanical vibration-isolated, liquid helium consumption-free cryogenic cooling device. The system according to some embodiments of the present disclosure comprises: a closed-cycle cryogenic cooling system, a helium heat exchange gas cooling and vibration isolation interface system, a cryogenic throttle valve cooling system, and a temperature feedback control system. The closed-cycle cooling system includes a cold head, a compressor, and a helium pipeline. The cryogenic throttle valve cooling system is thermally coupled to a low-temperature end of the cooling and vibration isolation interface.