A system and a method of managing a plurality of storage tiers, may include: receiving a write-access request, including at least one data element for storage, a logical address associated with the data element and a tier identifier for a selected tier; computing a unique reference name based on the content of the data element, and associating the unique reference name with the logical address; using a global API to generate a first write-access command, that includes the unique reference name and the data element; customizing the write-access command according to an addressing scheme of the selected tier by a dedicated driver, to obtain at least one second write-access command; using the second write-access command to associate the unique reference name with at least one physical location on the selected tier; and storing the at least one data element at the associated at least one physical location.