A new approach is proposed that contemplates systems and methods to provide identification and mitigation of malware attack via Web assets hosted on a Web application, site, or platform in an automated and proactive manner. From the moment the Web assets are hosted on the Web application platform and protected by a Web application security device, the hosted Web assets are constantly monitored and assessed for potential risks. Whenever there is a new instance or a modification of a Web asset, a copy of the Web asset is automatically downloaded and analyzed for potential vulnerabilities. If a suspicious indicator of malicious contents in the Web asset is detected during the analysis, a plurality of security policies are created and applied to the Web application security device to mitigate threats of the Web asset and protect users of the Web application against malware attacks via the tampered Web asset.