In a system and method for processing and implementing product regulations at a retail enterprise, a list is received by a retail server of products offered for sale by the enterprise that are regulation eligible, the received list of products is compared with product data identifying products offered for sale to all customers of the enterprise, each product in a database of the enterprise that matches a product in the list and that is not already marked therein as regulation eligible is marked as regulation eligible, and for each product so marked at least one characteristic of the product upon which regulation eligibility is based is determined, the database is searched to identify similar products that include the at least one characteristic, and for each identified similar product a request is transmitted for a determination of regulation eligibility thereof.