The present invention relates to systems and methods for identifying a biomarker from associative and knowledge based systems and processes. Particularly, aspects of the present invention are directed to a computer implemented method that includes data mining one or more public sources of biomedical text, scientific abstract, or bioinformatic data using queries to identify database terms associated with one or more predetermined terms, scoring association(s) between each of the identified database terms and the one or more predetermined terms, determining a subset b based on the score of the association(s), developing an interaction network model comprising the database terms in subset b, interactions, and additional database terms using a combination of algorithms in a predetermined order, and identifying candidate biomarkers from the interaction network model based on a ranking of the database terms in subset b and the additional database terms in the interaction network model.