Radio frequency (RF) communication systems with dynamic waveform control and power boost are provided herein. In certain embodiments, an RF communication system includes a power amplifier configured to amplify an RF signal to generate an RF transmit signal for transmission over a time-division duplex (TDD) communication link having a duty cycle, and a transmitter configured to provide the RF signal to the power amplifier. The transmitter is operable to change a type of waveform of the RF signal from a first waveform type to a second waveform type in response to a decrease in a signal-to-noise ratio (SNR) of the TDD communication link, and to boost a power of the RF transmit signal by an amount based on the duty cycle.