A portable electronic device (PED) holder assembly and related methods. A PED holder assembly includes a PED holder assembly to which a PED is detachably attachable, an output connector adapted for connection to an input port of a PED held by the PED holder assembly, an assistance request button attached to the PED holder assembly, a connection cable assembly operatively connected to the output connector and the assistance request button, and a bed-side connector assembly adapted to be connected to a bed-side end of a multifunctional assistance request cable. The bed-side connector assembly is operatively connected to the output connector, via the connection cable assembly, to transmit power received from the multifunctional assistance request cable to the PED. The bed-side connector is operatively connected to the assistance request button to transmit an assistance request signal generated via a pressing of the assistance request button through the multifunctional assistance request cable.