Provided are a CIS system and a method of processing the same using a low power multi-mode data path. In order to drive a circuit with low-power, the CMOS Image Sensor (CIS) system rearranges and transmits data in consideration of a color of pixel data and a most significant bit (MSB) and a least significant bit (LSB) of the pixel data using a low-power multi-mode data path. The CIS system can implement multi-modes including a low power mode and a high speed mode, reduce the number of data transitions by merging data of the same color in a always-on low-power mode and a photo-shooting low-power (PS-LP) mode to reduce power consumption and process data in a high speed using a pipeline in a photo-shooting high-speed (PS-HS) mode.