Invention Grant
- Patent Title: Anti-CSPG4 reagents and methods of treating cancer
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Application No.: US15564580Application Date: 2016-04-06
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Publication No.: US10881711B2Publication Date: 2021-01-05
- Inventor: Soldano Ferrone , Xinhui Wang
- Applicant: THE GENERAL HOSPITAL CORPORATION
- Applicant Address: US MA Boston
- Assignee: THE GENERAL HOSPITAL CORPORATION
- Current Assignee: THE GENERAL HOSPITAL CORPORATION
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Nicole D. Kling
- International Application: PCT/US2016/026141 WO 20160406
- International Announcement: WO2016/164408 WO 20161013
- Main IPC: C07K16/00
- IPC: C07K16/00 ; A61K39/395 ; A61K38/17 ; C07K14/47 ; A61K45/06 ; C07K16/30 ; G01N33/574 ; A61P35/00 ; A61K38/00
Abstract:
Embodiments of the present invention provide antibodies, antigen binding portions thereof, and other polypeptides (e.g., CARs), that specifically bind to CSPG4, an antigen expressed on cancer cells. Monoclonal antibodies, antibody-drug conjugates, and/or CAR-T-cells that specifically bind to CSPG4 positive cancer cells are also provided.
Public/Granted literature
- US20180072811A1 ANTI-CSPG4 REAGENTS AND METHODS OF TREATING CANCER Public/Granted day:2018-03-15
Information query
