Invention Grant
- Patent Title: Immunomodulatory therapeutic MRNA compositions encoding activating oncogene mutation peptides
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Application No.: US16279372Application Date: 2019-02-19
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Publication No.: US10881730B2Publication Date: 2021-01-05
- Inventor: Eric Yi-Chun Huang , Sze-Wah Tse , Jared Iacovelli , Kristine McKinney , Nicholas Valiante
- Applicant: ModernaTX, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ModernaTX, Inc.
- Current Assignee: ModernaTX, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Amy E. Mandragouras, Esq.; Ariana D. Harris
- Main IPC: A61K39/39
- IPC: A61K39/39 ; A61K9/50 ; C07K14/725 ; A61K39/00 ; A61K9/00 ; A61K9/51 ; A61P35/00 ; A61K35/00
Abstract:
The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.
Public/Granted literature
- US20190175727A1 IMMUNOMODULATORY THERAPEUTIC MRNA COMPOSITIONS ENCODING ACTIVATING ONCOGENE MUTATION PEPTIDES Public/Granted day:2019-06-13
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