A vehicle side structure includes a reinforcement extending upward from a rear wheel well, a side outer panel placed outward of the rear wheel well and the reinforcement in the vehicle width direction, a striker configured to lock a rear side door, and a bracket to which the striker is attached. An engaged portion is provided in the reinforcement, the striker is placed on an outer side of the side outer panel, and the bracket is provided with an engaging portion configured to engage with the engaged portion.