Invention Grant
- Patent Title: Compounds for treating prostate cancer
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Application No.: US15023349Application Date: 2014-09-18
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Publication No.: US10882834B2Publication Date: 2021-01-05
- Inventor: Peter Wipf , Erin M. Skoda , Zhou Wang
- Applicant: University of Pittsburgh—of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2014/056369 WO 20140918
- International Announcement: WO2015/042297 WO 20150326
- Main IPC: A61K31/495
- IPC: A61K31/495 ; C07D295/185 ; C07D295/192 ; A61K45/06 ; C07D295/26 ; C07D213/70 ; C07D333/16 ; C07D261/08 ; C07D317/54 ; C07D413/12 ; A61K31/4525 ; A61K31/551 ; A61K31/58 ; A61K31/496

Abstract:
A compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: R20—(Z)b—(Y)c—(R21)a—X—R22—R23 wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(=0)- or —S(=0)(=0)-; R22 is a moiety that includes at least one divalent amino radical; R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; a is 0 or 1; b is 0 or 1; and c is 0 or 1; provided that if X is —C(=0)- then Y is not S.
Public/Granted literature
- US20160264540A1 COMPOUNDS FOR TREATING PROSTATE CANCER Public/Granted day:2016-09-15
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