Invention Grant
- Patent Title: KDM1A inhibitors for the treatment of disease
-
Application No.: US16445768Application Date: 2019-06-19
-
Publication No.: US10882835B2Publication Date: 2021-01-05
- Inventor: John M. McCall , Hugh Y. Rienhoff, Jr. , Michael Clare
- Applicant: Imago Biosciences, Inc.
- Applicant Address: US CA San Carlos
- Assignee: Imago Biosciences, Inc.
- Current Assignee: Imago Biosciences, Inc.
- Current Assignee Address: US CA San Carlos
- Agent Dennis A. Bennett; Cynthia Hathaway; John Desper
- Main IPC: C07D295/192
- IPC: C07D295/192 ; C07D213/81 ; C07D233/90 ; C07D295/185 ; C07D295/26 ; C07D215/14 ; C07C237/22 ; A61K31/166 ; A61K31/40 ; A61K31/4453 ; A61K31/454 ; A61K31/4545 ; A61K31/47 ; A61K31/495 ; A61K31/5375 ; A61K31/54
Abstract:
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
Public/Granted literature
- US20200095214A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE Public/Granted day:2020-03-26
Information query
