Invention Grant
- Patent Title: Nucleic acid encoding angiopoietin-2 specific Tie2 receptor
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Application No.: US16230595Application Date: 2018-12-21
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Publication No.: US10882895B2Publication Date: 2021-01-05
- Inventor: Nicolas Phillip James Brindle , Julian Edward Sale
- Applicant: UNITED KINGDOM RESEARCH AND INNOVATION
- Applicant Address: GB Swindon
- Assignee: UNITED KINGDOM RESEARCH AND INNOVATION
- Current Assignee: UNITED KINGDOM RESEARCH AND INNOVATION
- Current Assignee Address: GB Swindon
- Agency: Marshall, Gerstein & Borun LLP
- Priority: GB1223053.8 20121220
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C07K14/71 ; A61K38/17 ; C12N9/12
Abstract:
In one aspect, provided herein is a polypeptide comprising a modified angiopoietin receptor or fragment thereof, wherein the polypeptide binds preferentially to angiopoietin-2 compared to angiopoeitin-1. Nucleic acid sequences encoding the polypeptide, as well as pharmaceutical uses of the polypeptide in treating diseases such as cancer and inflammation are also provided.
Public/Granted literature
- US20190218273A1 ANGIOPOIETIN-2 SPECIFIC TIE2 RECEPTOR Public/Granted day:2019-07-18
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