Invention Grant
- Patent Title: Recombinant obligate anaerobic Gram-positive bacteria
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Application No.: US16279627Application Date: 2019-02-19
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Publication No.: US10882912B2Publication Date: 2021-01-05
- Inventor: Takeshi Nishikawa , Yuichiro Taira , Ikuko Taira , Isao Ishida
- Applicant: TEIKYO HEISEI UNIVERSITY
- Applicant Address: JP Tokyo
- Assignee: TEIKYO HEISEI UNIVERSITY
- Current Assignee: TEIKYO HEISEI UNIVERSITY
- Current Assignee Address: JP Tokyo
- Agency: Lucas & Mercanti, LLP
- Priority: JP2014-003441 20140110
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K35/74 ; C12N15/74 ; A61K39/00
Abstract:
An object of the present invention is to effectively induce cancer cell apoptosis using the anti-TRAIL-R1 antibody(ies) and the anti-TRAIL-R2 antibody(ies) and to reduce the toxicity imposed on normal cells. The present invention relates to recombinant obligate anaerobic Gram-positive bacteria that include a nucleic acid encoding a fusion protein having 3 or more anti-TRAIL-R1 single-chain antibodies and/or 3 or more anti-TRAIL-R2 single-chain antibodies, in an expressible state.
Public/Granted literature
- US20190169305A1 RECOMBINANT OBLIGATE ANAEROBIC GRAM-POSITIVE BACTERIA Public/Granted day:2019-06-06
Information query
