- Patent Title: Variants of acetylserotonin O-methyltransferase and uses thereof
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Application No.: US16302124Application Date: 2017-05-24
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Publication No.: US10883127B2Publication Date: 2021-01-05
- Inventor: Hao Luo
- Applicant: DANMARKS TEKNISKE UNIVERSITET
- Applicant Address: DK Kgs. Lyngby
- Assignee: DANMARKS TEKNISKE UNIVERSITET
- Current Assignee: DANMARKS TEKNISKE UNIVERSITET
- Current Assignee Address: DK Kgs. Lyngby
- Agency: McHale & Slavin, P.A.
- Priority: EP16171032 20160524
- International Application: PCT/EP2017/062513 WO 20170524
- International Announcement: WO2017/202897 WO 20171130
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C12P17/10

Abstract:
Described herein are variants of acetylserotonin O-methyltransferase (ASMT) as well as vectors and recombinant microbial host cells expressing such ASMT variant and their use in producing melatonin and related compounds. Preferred ASMT variants provide for a higher turnover of N-acetylserotonin into melatonin.
Public/Granted literature
- US20190169662A1 VARIANTS OF ACETYLSEROTONIN O-METHYLTRANSFERASE AND USES THEREOF Public/Granted day:2019-06-06
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