Example systems and methods are described that operate to open screen joints using mechanically-generated perforations for beginning fluid production. In an example system, a screen joint is deployed in a production tubing within a wellbore. The screen joint includes a screen element and a blank housing that are coupled to an exterior surface of a non]perforated base pipe. Further, the screen joint includes a locator profile positioned along an interior surface of the non]perforated base pipe. A perforator is deployed within the screen joint that includes a mechanical perforator and a locator for engaging with the locator profile to position the mechanical perforator under the blank housing.