The invention provides an air purifier with independent duel channel, which has separate first channel portion and second channel portion, wherein the first channel portion is used to filter particulate matters in the air and the second channel portion is used to purify the air. The invention mainly separates the channels and processes of the filtered air and the purified air, and more matches the selection of specific suction fan and intake fan so as to meet the different flow velocities required for air filtration and purification respectively, thereby achieving the optimal air filtration and purification effects, and improving the ineffective problem caused by the simultaneous filtration and purification of the air in the same channel of the existing air purifier.