Disclosed herein are systems and techniques for serial peripheral interface (SPI) functionality for node transceivers in a two-wire communication bus. For example, in some embodiments, a node transceiver may include SPI circuitry and upstream or downstream transceiver circuitry. SPI commands received via the SPI circuitry may be executed by the node transceiver, or transmitted upstream or downstream along the two-wire bus for execution by another node transceiver or a slave device coupled to another node transceiver.