Methods and devices for synchronizing audio among a plurality of display devices in communication with a computer device may include determining a plurality of audio data subsets with audio data from an audio stream to transmit to a plurality of display devices in communication with the computer device via a universal serial bus (USB) connection. The methods and devices may include obtaining a current frame number of a display device render buffer from a first display device of the plurality of display devices. The methods and devices may include determining an updated frame number by adding a constant to the current frame number; and generating a plurality of USB request blocks with the updated frame number and packets with the plurality of audio data subsets. The methods and devices may include sending the USB request blocks to a corresponding display device of the plurality of display devices.