A system including a healthcare risk engine to provide a healthcare risk knowledge graph from open data and knowledge data related to risk by using risk-related terms to retrieve documents from open data and by extracting the healthcare risk knowledge graph as entities from the documents and links between the entities. A patient risk graph predictor predicts risks for a patient by combining information in a Patient Clinical Object (PCO) with entities in the healthcare risk knowledge graph to produce a patient risk graph. An impact estimator estimates an impact of a treatment by taking the treatment and adjacent nodes from the healthcare risk knowledge graph to form a healthcare treatment subgraph, finding an entity and adjacent nodes in the patient risk graph to form a patient treatment subgraph, providing an impact graph by combining the patient treatment subgraph and the healthcare treatment subgraph, and retaining resultant linked nodes.