A system, method and program product for obfuscating audible messages in a listening space A system is provided that includes an orchestrator having: an invocation detection system that triggers an obfuscation event; a system for selecting injector nodes in the listening space for the obfuscation event; and a key management system that distributes keys, derived from a natural interface key, to the injector nodes to cause the injector nodes to inject sounds into the listening space to obfuscate an audible message broadcast by a source node for a target node; and a machine learning system that calculates the natural interface key based on interactions captured from the source node in the listening space.