A transform-enabled integrated circuit is provided with a combined transformation/hashing block, such as for cryptographic proof-of-work systems. The transform-enabled integrated circuit embeds components for a transformation function among hashing function components within the cryptographic datapath of the transform-enabled integrated circuit. The combined transformation/hashing block may be configured after the manufacture of the integrated circuit to embody as circuitry any one of a plurality of mathematical transformation functions, thus enabling a user to systemically modify the cryptographic operations performed by the integrated circuit while retaining the high performance and efficiency characteristics of application specific integrated circuits. Embodiments modify the internal intermediate state variables of the hashing function to transform and hash an input message. Method and computer program product embodiments are also provided. The technology flexibly enables the deployment of application-specific integrated circuits (ASICs) within blockchain systems, digital rights management, secure token, and other cryptography-related fields.