A system and method for obtaining topologically optimized structure in additive manufacturing. A finite element mesh of a standard shape geometry encompassing desired structure to be optimized with a design objective and orthotropic properties of material arising out of a selected material and selected additive manufacturing process to be used for manufacturing. An iterative topology optimization is carried out wherein the process includes simulation of loading requirements, design constraints and the boundary condition. The performance evaluation process uses a finite element analysis framework to obtain the factor of safety between two consecutive iterations based on the anisotropic properties of the material. The process will achieve a minimal factor of safety and a best suitable build orientation of the design.