Systems and methods for operating a screen activity moderated skill wagering interleaved game are disclosed. A screen activity moderated skill wagering game is provides an entertainment game and a gambling game. The entertainment game is provided by an entertainment system and is managed by a game world operating system. The gambling game is provided by a real credit operating system. The screen activity moderated skill wagering interleaved game also provides screen activity moderation to adjust gambling activity based on the level of screen activity within the entertainment game. During periods of high intensity game play within the entertainment game, the screen activity moderated skill wagering interleaved game in some embodiments adjusts the gambling activity within the gambling game inversely based on the level of screen activity.