Various systems and methods are disclosed to allow users to conveniently control characteristics of sounds generated by musical instruments. Exemplary systems include a control unit in communication with any number of audio processing devices (“APDs”). The control unit may be operable to transmit control signals to each of the APDs, wherein the control signals include settings information relating to one or more APD processing parameter values. The control unit may be further operable to receive an audio signal generated by an instrument and transmit the same to the APDs. Accordingly, upon receiving the control signal and the audio signal from the control unit, the APDs may update their processing parameters based on relevant settings information contained in the control signal and process the audio signal into a processed audio signal, based on the updated processing parameters.