Disclosed a drive method, a drive circuit for a power switch and a power supply system. During the turning-on period of the power switch, which can be roughly divided into three processes, a current limiting module is used to limit the current flowing through the power switch for preventing current overshoot, a logic control module is used for controlling the current limiting module not to operate before the turning-on period and the control terminal of the power switch is turned off; during the turning-on period, a feedback circuit adjusts the gate voltage of the power switch for controlling the current flowing through the power switch to reach a predetermined limited value quickly and then maintain at the limited value until the power switch is fully turned on. The current limiting module can be employed in various embodiments. According to the disclosure, the current flowing through the power switch can be effectively controlled during the turning-on period, and the driving time for turning on the power switch is decreased.