Invention Grant
- Patent Title: Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
-
Application No.: US15503210Application Date: 2015-08-12
-
Publication No.: US10888567B2Publication Date: 2021-01-12
- Inventor: Brian Desmond Palmer , Lai Ming Ching , Swarnalatha Akuratiya Gamage
- Applicant: AUCKLAND UNISERVICES LIMITED
- Applicant Address: NZ Auckland
- Assignee: AUCKLAND UNISERVICES LIMITED
- Current Assignee: AUCKLAND UNISERVICES LIMITED
- Current Assignee Address: NZ Auckland
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: NZ628688 20140813
- International Application: PCT/IB2015/056129 WO 20150812
- International Announcement: WO2016/024233 WO 20160218
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K45/06 ; A61K31/444 ; A61K31/519 ; A61K31/437 ; C07D498/04 ; A61K31/4745 ; A61K31/423
Abstract:
Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
Public/Granted literature
- US20170224701A1 INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY Public/Granted day:2017-08-10
Information query
IPC分类:
