Invention Grant
- Patent Title: Methods of treating cancer cells expressing tumor-associated integrins
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Application No.: US16076597Application Date: 2017-02-10
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Publication No.: US10888603B2Publication Date: 2021-01-12
- Inventor: Karl Dane Wittrup , Darrell J. Irvine , Cary Francis Opel , Kelly Dare Moynihan , Jennifer R. Cochran , Byron Hua Kwan
- Applicant: Massachusetts Institute of Technology , The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US MA Cambridge; US CA Stanford
- Assignee: Massachusetts Institute of Technology,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: Massachusetts Institute of Technology,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US MA Cambridge; US CA Stanford
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Amy E. Mandragouras, Esq.; Ariana D. Harris
- International Application: PCT/US2017/017365 WO 20170210
- International Announcement: WO2017/139570 WO 20170817
- Main IPC: A61K38/20
- IPC: A61K38/20 ; A61K39/00 ; A61K39/395 ; A61K38/16 ; C07K16/28 ; A61K39/12 ; A61K47/64 ; A61K47/60 ; A61K47/68 ; A61P35/00 ; C07K16/30
Abstract:
The present invention provides a method of treating cancer with a combination of IL-2 (e.g., extended-PK IL-2), an integrin-binding-Fc fusion protein, and a cancer vaccine. The methods of the invention can be used to treat a broad range of cancer types.
Public/Granted literature
- US20190054145A1 SYNERGISTIC TUMOR TREATMENT WITH IL-2, AN INTEGRIN-BINDING-FC FUSION PROTEIN, AND A CANCER VACCINE Public/Granted day:2019-02-21
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