Invention Grant
- Patent Title: 4-amino-2-pyrido-bicyclic pyrimidines and use thereof as topoisomerase II inhibitors
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Application No.: US16472593Application Date: 2017-12-15
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Publication No.: US10889560B2Publication Date: 2021-01-12
- Inventor: Marco De Vivo , Jose Antonio Ortega Martinez , Jose Manuel Arencibia Jimenez , Anna Minarini , Claudia Sissi
- Applicant: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA , ALMA MATER STUDIORUM—UNIVERSITA' DI BOLOGNA , UNIVERSITA' DEGLI STUDI DI PADOVA
- Applicant Address: IT Genoa; IT Bologna; IT Padua
- Assignee: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA,ALMA MATER STUDIORUM—UNIVERSITA' DI BOLOGNA,UNIVERSITA' DEGLI STUDI DI PADOVA
- Current Assignee: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA,ALMA MATER STUDIORUM—UNIVERSITA' DI BOLOGNA,UNIVERSITA' DEGLI STUDI DI PADOVA
- Current Assignee Address: IT Genoa; IT Bologna; IT Padua
- Agency: Troutman Pepper Hamilton Sanders LLP (Rochester)
- Priority: IT102016000130706 20161223
- International Application: PCT/EP2017/083087 WO 20171215
- International Announcement: WO2018/114700 WO 20180628
- Main IPC: C07D401/04
- IPC: C07D401/04 ; A61K33/243 ; A61K31/167 ; A61K31/282 ; A61K31/337 ; A61K31/357 ; A61K31/407 ; A61K31/4745 ; A61K31/475 ; A61K31/513 ; A61K31/517 ; A61K31/519 ; A61K31/655 ; A61K31/704 ; A61K31/706 ; A61K31/7076 ; C07D471/04
Abstract:
The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines of Formula (I) that function as type II topoisomerase inhibitors and their use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4-amino-2-pyrido bicyclic pyrimidines of Formula (I).
Public/Granted literature
- US20190315709A1 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS Public/Granted day:2019-10-17
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