There are provided a medical image processing device, an endoscope system, a diagnosis support device, and a medical service support device that can provide appropriate diagnosis support information from a region of interest by appropriately extracting the region of interest. An image acquisition unit acquires a medical image obtained from the image pickup of an object to be observed. A region-of-interest extraction section extracts a first region of interest as a region of interest from the medical image. A region-of-interest change section performs correction processing for correcting the first region of interest to a second region of interest. A user interface receives an instruction given to the region-of-interest change section. The correction processing includes the enlargement, the reduction, or the position change of the first region of interest.