- Patent Title: Functional hydrated hyaluronic acid and method for producing coated lactic acid bacteria having excellent intestinal mucoadhesive ability and selective antagonistic action using same
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Application No.: US15760166Application Date: 2016-09-19
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Publication No.: US10894086B2Publication Date: 2021-01-19
- Inventor: Seung-Hun Lee , Dae Jung Kang , Jae-Hoon Kang
- Applicant: ILDONG PHARMACEUTICAL CO., LTD.
- Applicant Address: KR Seoul
- Assignee: ILDONG PHARMACEUTICAL CO., LTD.
- Current Assignee: ILDONG PHARMACEUTICAL CO., LTD.
- Current Assignee Address: KR Seoul
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- Priority: KR10-2015-0129986 20150914
- International Application: PCT/KR2016/010415 WO 20160919
- International Announcement: WO2017/048098 WO 20170323
- Main IPC: A61K35/744
- IPC: A61K35/744 ; A61K35/745 ; A61K35/747 ; A61K35/74 ; A61K47/36 ; A61K47/10 ; A61K47/14 ; A61K47/32 ; A61K47/38 ; A61K47/42 ; A61K9/50 ; C12N1/20 ; C08B37/08 ; C08L5/08 ; C08L5/00 ; C08L89/00 ; C08L93/00 ; C09D105/08 ; A23L33/135 ; A23L5/00 ; A61P1/00 ; A61P1/14 ; C07K14/47 ; C07K14/415

Abstract:
The present invention relates to a functional hydrated hyaluronic acid and a method for producing 5th generation coated lactic acid bacteria having excellent intestinal mucoadhesive ability and a selective antagonism using the same and, more specifically, to a functional hydrated hyaluronic acid in which components fermented by lactic acid bacteria are captured in hyaluronic acid, which is a natural polymer substance, and a method for producing coated lactic acid bacteria using the same. The quadruply coated lactic acid bacteria coated using the functional hydrated hyaluronic acid according to the present invention is quadruply coated with a water-soluble polymer, a functional hydrated hyaluronic acid, a coating agent having porous particles, and a protein, thereby producing an excellent intestinal mucoadhesive ability, exhibiting an antibacterial action against deleterious bacteria in the intestines, and promoting growth of beneficial bacteria in the intestines.
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