A vehicle framework structure includes: a framework body portion extending in a vehicle front-rear direction in a vehicle end portion in a vehicle width direction, the framework body portion forming a closed section by an inner panel constituting an inner part of the framework body portion in the vehicle width direction and an outer panel constituting an outer part of the framework body portion in the vehicle width direction; and a reinforcing member placed inside the closed section of the framework body portion, the reinforcing member including a body portion inclined from the vehicle front-rear direction and provided over the inner panel and the outer panel, and a flange portion extending from an outer peripheral edge of the body portion and joined to the inner panel and the outer panel.