A method of controlling an isolated converter can include: (i) sampling and holding an output voltage of the isolated converter during a present switching cycle to generate a reference voltage signal that is proportional to the output voltage; (ii) comparing, in a predetermined time interval before a next switching cycle, the output voltage against the reference voltage signal, and activating a wake-up signal when the output voltage is less than the reference voltage signal, in order to control a voltage at a secondary winding to represent a variation of the output voltage; (iii) detecting a voltage of the primary winding or the secondary winding, and generating a voltage detection signal; and (iv) controlling the power switch according to the voltage detection signal, in order to maintain the output voltage as an expected voltage.